Metabolism Resmetirom is metabolized by CYP2C8 and is not metabolized by other CYP enzymes in vitro. MGL-3623 is A significant metabolite that has a 28-times reduce potency for THR-? than resmetirom.Abbreviations: AUCtau,ss = area beneath the concentration-vs .-time curve more than a single dosing interval at regular point out; Cmax,ss = highest f